Qualitative and quantitative analysis of the action of typical and atypical antidepressants in the experimental animal.

For a liiiig tiine nntiilrpressants Iiave beeii rrprrsente11 inninly hy t,ricyclic coinpoiinds (i iniprm~inc griiip) ni1d 1)y M A 0 iiiliihitor8 (Iiy~lrnsine (lerivntivrs). New nntidepressant drugs incliiilc inolia-, h , triand tctra-<lyclic conipoiinrls; nniong tlizin n Iarge group iu coiistituted hy atypicd men, i?. , Iiy i lr i ip ivliicli do not share on the experiiiwntal aitimal tlir i,fkcts uf the irnipraiiiiiic or of the hydraeine derivativrs. Preclinicnl stiidy of th tm ntypical nntirlepresmnts i* difficiilt bccaiisr of th r insiifficiently clevrlo~ieil Iicliavioiirnl inodeln of ilrpressive statcx arid of iiliiective riiet~hoils <if eva,luati~in i ~ f t,hrse stat,ex. The wtriety 01' tlie cliiiicnl fririiiy of ilcprcssii~ii calls iiir t,he filrmiitii~ri «f iliffercnt ii~oilels, I i e c a u ~ t,he aiitirlcprcssniit~s psychotropic cffrct i n rzlated ti, t,he nianifi:stationu whicli cliniartriim tlie vnrioiia fornis of rlcprrssiun. Ttiis work p r c s ~ n t , ~ tlic rrsiilts rif a stiidy of tlie activity slicctruin iif ;in ntypicnl nnt~iilzprrnsaiitn srrirs (in runiparison with classic " oiirs) mi IL iiio~lel iif prolongeil Iirlinvioiirnl dr1irvsuion i r i wtn.